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Precision Nanomedicine

The official journal of CLINAM

Precision Nanomedicine (PRNANO) is an open-access, not-for-profit journal that promotes all practical, rational and progressive aspects of nanomedicine.

Authors are invited to submit both original and replication studies. Discussions of negative results are also welcome.

2019 SUBMISSIONS ARE FREE - NO APC IN 2019 

PRNANO is digitally distributed by a scientists-owned non-profit publisher: Andover House Inc, 138 River Rd, Massachusetts, 01810, USA. E-ISSN: 2639-9431

Nanoparticle-Encapsulated Doxorubicin Demonstrates Superior Tumor Cell Kill in Triple Negative Breast Cancer Subtypes Intrinsically Resistant to Doxorubicin
- Krausz AE, Adler BL, Makdisi J, Schairer D, Rosen J, Landriscina A, Navati M, Alfieri A, Friedman JM, Nosanchuk JD, Rodriguez-Gabin A, Ye KQ, McDaid HM, Friedman AJ.
Liposomal formulation of polyacrylate-peptide conjugate as a new vaccine candidate against cervical cancer
- Khongkow M, Liu TY, Bartlett S, Hussein WM, Nevagi R, Jia ZF, Monteiro MJ, Wells J, Ruktanonchai UR, Skwarczynski M, Toth I.
Specific Molecular Recognition as a Strategy to Delineate Tumor Margin Using Topically Applied Fluorescence Embedded Nanoparticles
- Barton S, Li B, Siuta M, Janve VA, Song J, Holt CM, Tomono T, Ukawa M, Kumagai H, Tobita E, Wilson K, Sakuma S, Pham W.
Nanotherapy Targeting NF-kappaB Attenuates Acute Pain After Joint Injury
- Yan H, Duan X, Collins KH, Springer LE., Guilak FE, Wickline SA, M. Rai F, Pan H, Pham CTN
Simultaneous release of two drugs from polymer nano-implant inhibits recurrence in glioblastoma spheroids
- Devassy G, Ramachandran R, Jeena K, Junnuthula VR, Gopinatha VK, Manju CA, Manohar M, Nair SV, Raghavan SC, Koyakutty M.
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RECENT PUBLICATIONS:

Precision Nanomedicine, 2019 January; Vol. 2, Issue 1

(in progress)

Precision nanomedicine in atherosclerosis therapy: how far are we from reality?

Wong YS, Bertrand C, Venkatraman SS, Precision nanomedicine in atherosclerosis therapy: how far are we from reality? Prec. Nanomed. 2019 Jan;2(1):226-241. https://doi.org/10.33218.prnano182018.1

(Accepted review)

Nanotherapy Targeting NF-kappaB Attenuates Acute Pain After Joint Injury,

Communication

Yan H, Duan X, Collins KH, Springer LE., Guilak FE, Wickline SA, M. Farooq Rai F, Pan H, Pham CTN, Prec. Nanomed. 2019 Jan;2(1):223-226

Simultaneous release of dual drugs from polymer nano-implant inhibits recurrence in glioblastoma spheroids

Research article

Devassy G, Ramachandran R, Jeena K, Junnuthula VR, Gopinatha VK, Manju CA, Manohar M, Nair SV, Raghavan SC, and Koyakutty M, Prec. Nanomed. 2019 Jan;2(1):211-222

Precision Nanomedicine, 2018 October; Vol. 1, Issue 3

FEATURED RESEARCH ARTICLE

Liposomal formulation of polyacrylate-peptide conjugate as a new vaccine candidate against cervical cancer, Khongkow M, Liu TY, Bartlett S, Hussein WM, Nevagi R, Jia ZF, Monteiro MJ, Wells J, Ruktanonchai UR, Skwarczynski M, Toth I, Prec. Nanomed. 2018 Oct;1(3):186-196.

In this study, the authors describe the improvement of vaccine delivery via using a polymer-based delivery system. Authors demonstrate that the combination of polymer-based and liposome delivery systems may be effective without the use of additional adjuvant and with just a single-dose immunization.

RESEARCH ARTICLES

Nanoparticle-Encapsulated Doxorubicin Demonstrates Superior Tumor Cell Kill in Triple Negative Breast Cancer Subtypes Intrinsically Resistant to Doxorubicin, Krausz AE, Adler BL, Makdisi J, Schairer D, Rosen J, Landriscina A, Navati M, Alfieri A, Friedman JM, Nosanchuk JD, Rodriguez-Gabin A, Ye KQ, McDaid HM, Friedman AJ, , Prec. Nanomed. 2018 Oct;1(3):172-185.

The treatment of triple-negative breast cancer is often difficult due to frequent resistance to doxorubicin. Using different nano-formulations based on sol-gel technology to encapsulate doxorubicin, the authors here showed enhanced dose-response metrics and tumor cell kill of these cancer cells due to an increased drug accumulation in the local tumor environment.Specific Molecular Recognition as a Strategy to Delineate Tumor Margin Using Topically Applied Fluorescence Embedded Nanoparticles, Barton S, Li B, Siuta M, Janve VA, Song J, Holt CM, Tomono T, Ukawa M, Kumagai H, Tobita E, Wilson K, Sakuma S, Pham W. Prec. Nanomed. 2018 Oct;1(3):197-210.

The ability to delineate the tumor accurately during operation is important to ensure all tumor cells are resected. Here, the authors describe the development of a multimodal imaging probe using nanospheres to target epithelial cells of pancreatic cancer. The specificity to target only tumor cells was clearly shown in both in-vitro and in-vivo experiments.

Plasma samples from mouse strains and humans demonstrate different susceptibilities to complement activation, Neun BW, Szénási G, Szebeni J, Dobrovolskaia M., Prec. Nanomed. 2018 Oct;1(3):211-220.

The authors describe the importance of mouse strain selection for in vitro complement activation analysis addressing also the existence of inter- and intraspecies variability.

Precision Nanomedicine, 2018 July; Vol. 1, Issue 2

FEATURED RESEARCH ARTICLE

Cellular Trafficking of Sn-2 Phosphatidylcholine Prodrugs Studied with Fluorescence Lifetime Imaging and Super-resolution Microscopy; Maji D, Lu J, Sarder P, Schmieder AH, Cui G, Yang X, Pan D, Lew MD, Achilefu S, Lanza GM. Prec. Nanomed. 2018 July;1(2):127-145.

PERSPECTIVE

Skin Biosensing and Bioanalysis: What the Future Holds; Ng KW, Moghimi SM. Prec. Nanomed. 2018 July;1(2):124-127.

REVIEW

A Coming Era of Precision Diagnostics Based on Nano-assisted Mass Spectrometry; Li RX, Gurav DD, Wan JJ, Qian K. Prec. Nanomed. 2018 July;1(2):162-172.

RESEARCH ARTICLES

Rational Design of a siRNA Delivery System: ALOX5 and Cancer Stem Cells as Therapeutic Targets, Rafael D, Andrade F, Montero S, Gener P, Seras-Franzoso J, Martínez F, González P, Florindo H, Arango D, Sayós J, Abasolo I, Videira M, Schwartz Jr. S.  Prec. Nanomed. 2018 July;1(2):86-105. Lysozyme transport to the brain by Liposomes; Nordling-David MM, Rachmin E, Etty Grad E, Golomb G, Prec. Nanomed. 2018 July;1(2):146-161.Retinal Multipotent Stem-Cell Derived “MiEye” Spheroid 3D Culture Model for Preclinical Screening of Non-viral Gene Delivery Systems,; Chen DW, Foldvari M. Prec. Nanomed. 2018 July;1(2):106-123.

Precision Nanomedicine, 2018 April; Vol. 1, Issue 1

EDITORIALS

The Story of Precision Nanomedicine – the Journal; Lajos P Balogh, Prec. Nanomed. 2018, Apr; 1(1):1-4. Balancing Interests of Science, Scientists, and the Publishing Business; Lajos P Balogh, Prec. Nanomed. 2018, Apr; 1(1):5-14. Improving Innovation in Nano-Healthcare Funding, Mike Eaton, Prec. Nanomed. 2018 Apr; 1(1):15-17.

FEATURED RESEARCH ARTICLE

Immunocompatibility of Rad-PC-Rad liposomes in vitro, based on human complement activation and cytokine release; Matviykiv S, Buscema M, Gerganova G, Mészáros T, Kozma GT, Mettal U, Neuhaus F, Ishikawa T, Szebeni J, Zumbuehl A, Müller B. Prec. Nanomed. 2018 Apr;1(1):43-62.

COMMUNICATION

Discrepancies in the in vitro and in vivo role of scavenger receptors in clearance of nanoparticles by Kupffer cells; Wang G, Groman E, Simberg D. Prec. Nanomed. 2018 Apr;1(1):76-85.

REVIEWS

Origins to Outcomes: A Role for Extracellular Vesicles in Precision Medicine; Savage, J, Maguire, CM, Prina-Mello A. Prec. Nanomed. 2018, Apr; 1(1):18-42.A porcine model of complement activation-related pseudoallergy to nanopharmaceuticals: Pros and cons of translation to a preclinical safety test; Szebeni J, Bedőcs P, Dézsi L, Urbanics R. Prec. Nanomed. 2018 Apr;1(1):63-75.

Download PDF Views: 4041     Downloads: 97

Editor-in-Chief Lajos P. Balogh PhD

Clinical Editor Kenneth KY Wong, MD, PhD
Christoph Alexiou, MD

Associate Editors Marina A. Dobrovolskaia, PhD
Marianna Földvári, D.Pharm.Sci., PhD
Adam Friedman, MD
Marc F. Hansen, PhD
Rodney Hill, PhD
Manzoor Koyakutty, PhD
Gregory M. Lanza, MD, PhD
Dong Soo Lee, MD, PhD
Yuri L. Lyubchenko, PhD, DSc
S. Moein Moghimi, PhD
Bert Müller, PhD
Lily Yang, MD, PhD

Honorary Board Yechezkel (Chezy) Barenholz PhD
Michelle Bradbury MD, PhD
Mike Eaton, PhD
Omid C. Farokhzad, MD
Peixuan Guo, PhD
Patrick Hunziker, MD
CN Lee, MD
Beat Löffler, MA, MD h.c.
Donald A. Tomalia, PhD
Yuliang Zhao, PhD
Xiangliang Yang, PhD

Editorial Board Managing Editor
Fatemah Atyabi, PhD
Roy Bicknell PhD
Massimo Bottini, PhD
Siu-Wai Chan, Ph.D.
Daxiang Cui, PhD
Mohamed E.H. ElSayed
Elias Fattal, PhD
Robert A. Freitas Jr. PhD
Howard E. Gendelman, MD
Gershon Golomb, PhD
África González-Fernández MD, PhD
Dean Ho, Ph.D.
Varvara Karagkiozaki M.D., MSc
Barbara Klajnert-Maculewicz, Ph.D., D.Sc.
Silke Krol, PhD
Claus-Michael Lehr PhD
Zifu Li, PhD
Yoav Livney, PhD
Wan-Liang Lu, PhD
Donald Mager, Pharm.D, PhD
Guangjun Nie, PhD
Andrew Owen PhD
Dan Peer PhD
Christine Pham, MD
Wellington Pham, PhD
David Pozo Perez PhD
Adriele Prina-Mello, PhD
Kun Qian, PhD
Vittoria Raffa, PhD
Eder Lilia Romero, PhD
Dmitri Simberg, PhD
Simó Schwartz Jr, MD. PhD
Youqing Shen, PhD
Eliana B. Souto, PhD
János Szebeni, MD, PhD
Istvan Toth, PhD DSc FRACI FQA
Subbu S. Venkatraman PhD
Yuri Volkov, MD
Gayle E. Woloschak, PhD