Click [here](https://img1.wsimg.com/blobby/go/79f8b7d6-8c8b-42a3-88c5-e510dd05e72e/PRNANO%20issue%201(2)%20Covernew.png.pdf) to download a hi-res image of the cover page ##FEATURE ARTICLE Greg Lanza et al., Cellular Trafficking of Sn-2 Phosphatidylcholine Prodrugs Studied with Fluorescence Lifetime Imaging and Super-resolution Microscopy [Prec. Nanomed. 2018;1(2):128-145.](https://doi.org/10.33218/prnano1(2).180724.1) BASIC RESEARCH _From the Clinical Editor:_ Sn-2 phosphatidylcholine prodrugs have been shown to be effective systemically for the delivery of a variety of drugs. Nonetheless, little is known about the pharmacokinetics in terms of cell uptake release and activation. Here, the authors have carried out experiments utilizing fluorescence microscopy, fluorescence lifetime imaging, and single-molecule super-resolution imaging techniques and show that the series of events that occur after the prodrugs had contacted with cellular membranes. The data has given valuable new understanding of prodrug pharmacokinetics. [ALTMETRICS and CITATIONS](https://andoverhouse.org/prnano-132018) **Perspectives** Moein Moghimi et al., Skin biosensing and bioanalysis: what the future holds [Prec. Nanomed. 2018;1(2):124-127](https://doi.org/10.33218/prnano1(2).180709.1) PERSPECTIVE _From the Clinical Editor:_ Wearable skin biosensors have important applications in health monitoring, medical treatment and theranostics. There has been a rapid growth in the development of novel biosensing and bioanalytical techniques in recent years, much of it underpinned by recent advancements in nanotechnology. As the two related disciplines continue to co-evolve, we take a timely look at some notable developments in skin biosensing/bioanalysis, scan the horizon for emerging nanotechnologies, and discuss how they may influence the future of biosensing/bioanalysis in the skin. [ALTMETRICS and CITATIONS](https://andoverhouse.org/prnano-102018) Kun Qian et al., A coming era of precision diagnostics based on nano-assisted mass spectrometry [Prec. Nanomed. 2018;1(2):162-172](https://doi.org/10.33218/prnano1(2).180724.2) BASIC RESEARCH _From the Clinical Editor:_ Precision diagnostics relies on omics analysis by mass spectrometry to overcome the limitation in accuracy by an individual biomarker, due to the complex nature of diseases. Recent development in nanotechnology markedly enhanced sample treatment and detection efficiency of this method. Herein, we foresee a coming era of precision diagnostics based on nano-assisted mass spectrometry. Some important progress in the field includes detection of (1) nucleic acids for genetic analysis; (2) proteins/peptides for proteomic analysis; and (3) small molecules for metabolic analysis. We anticipate that this review will be a reminder for both young and experienced researchers about the future of diagnostics and call for attention worldwide. [ALTMETRICS and CITATIONS](https://andoverhouse.org/prnano-142018) **Research articles** Simo Schwartz Jr. et al., Rational Design of a siRNA Delivery System: ALOX5 and Cancer Stem Cells as Therapeutic Targets [Prec. Nanomed. 2018;1(2):86-105.](https://doi.org/10.29016/180629.1) BASIC RESEARCH _From the Clinical Editor:_ The use of gene-silencing technique for cancer therapy has been met with problems like cellular uptake, degradation, and clearance. The authors here test two different types of polymeric particle formulations as vectors in an attempt to improve the biological efficacy and describe a general algorithm for testing. The data obtained provide more knowledge of how to further progress the field for the benefits of selected cancer patients. [SEE ALTMETRICS and CITATIONS](https://andoverhouse.org/prnano-82018) M. Foldvari et al., Retinal Multipotent Stem-Cell Derived “MiEye” Spheroid 3D Culture Model for Preclinical Screening of Non-viral Gene Delivery Systems [Prec. Nanomed. 2018;1(2):106-123](https://doi.org/10.29016/180711.1) BASIC RESEARCH _From the Clinical Editor:_ Gene therapy seems to be a promising modality for treating eye diseases. Non-viral retinal gene therapy theoretically should have an advantage over viral delivery system in terms of safety. However, non-viral system is hampered by low gene transfer efficacy in-vivo. The authors here describe a novel 3-D culture model of retinal stem cells to mimic in-vivo environment. This system should prove useful in testing the efficacy of gene transfer to retinal stem cells and predict in vivo performance. [ALTMETRICS and CITATIONS](https://andoverhouse.org/prnano-92018) Gershon Golomb et al., Lysozyme Transport to the Brain by Liposomes [Prec. Nanomed. 2018;1(2):146-161](https://doi.org/10.33218/prnano1(2).180712.1) BASIC RESEARCH _From the Clinical Editor:_ The almost impenetrable blood-brain barrier (BBB) is a problem faced by many researchers developing drug delivery systems for treating brain disorders. In this context, the authors here describe a new method in utilizing the phagocytic power of monocytes in order to get entry into the brain. Liposomes with specific properties were formulated and phagocytosed by monocytes were shown to be transported into the brain. This “stealth” approach may prove quite useful clinically in the future. [ALTMETRICS and CITATIONS](https://andoverhouse.org/prnano-112018)

Rational Design of a siRNA Delivery System: ALOX5 and Cancer Stem Cells as Therapeutic Targets

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