Click [here](https://img1.wsimg.com/blobby/go/07e8358d-95f4-491a-894f-2f68b592c366/PRNANO%206(4)%20Cover.jpg.pdf) to download a hi-res PDF copy of the cover page ##FEATURE ARTICLE: Guzman ML, Peralta MF, Quipildor M, Papera F, Mejía E, Lauthier JJ, Bono M, Barroso PA, Olivera ME, Carrer DC, A Case of Cutaneous Leishmaniasis Cured by a Combined Treatment of Topical Miltefosine and Injectable Amphotericin B, [Precis. Nanomed. 2023, 6(4):1179-1191](https://doi.org/10.33218/001c.90983) CLINICAL SIGNIFICANCE _From the Clinical Editor:_ Cutaneous leishmaniasis is a parasitic disease prevalent worldwide, especially in developing countries. The most critical clinical concern is the development of resistance to drug treatment. In this paper, the authors reported the successful treatment of a patient with cutaneous leishmaniasis using topical liposomal Miltefosine. This new formulation should pave the way to more extensive clinical trials in the future. [ALTMETRIC and CITATIONS](https://precisionnanomedicine.net/prnano-1012023) **Research Article** Alhussan A, Calisin R, Jackson N, Morgan J, Chen S, Tam YYC, Beckham W, Krishnan S, Chithrani DB, A Synergetic Approach Utilizing Nanotechnology, Chemotherapy, and Radiotherapy for Pancreatic Cancer Treatment, [Precis. Nanomed. 2023, 6(4):1157-1172](https://doi.org/10.33218/001c.90447) CLINICAL SIGNIFICANCE _From the Clinical Editor:_ This article describes a triple-modality treatment regime using gold- and drug-encapsulated lipid nanoparticles with radiotherapy, showing enhanced treatment efficacy in a pancreatic cancer model. [ALTMETRIC and CITATIONS](https://precisionnanomedicine.net/prnano-1112023-1) **Reviews** Pandey N, Ahmad F, Singh K, Ahmad S, Sharma R, Mushroom-Derived Nanoparticles in Drug Delivery Systems – Therapeutic Roles and Biological Functions, [Precis. Nanomed. 2023, 6(4):1157-1180](https://doi.org/10.33218/001c.91083) POTENTIAL CLINICAL SIGNIFICANCE _From the Clinical Editor:_ Along with synthesizing nanoparticles using traditional chemical methods, green synthesis by mushrooms can also be utilized as an eco-friendly technology. The review describes the various mushroom-derived nanoparticles and their potential capabilities in biomedical and clinical settings. [ALTMETRIC and CITATIONS](https://precisionnanomedicine.net/prnano-1042023) Ahmad F, Pandey N, Singh K, Ahmad S, Khubaib M, Sharma R, Recent advances in Nanocarrier based therapeutic and diagnostic approaches in Tuberculosis, [Precis. Nanomed. 2023, 6(4):1134-1156](https://doi.org/10.33218/001c.90699) CLINICAL SIGNIFICANCE _From the Clinical Editor:_ This comprehensive review describes the currently available various nanotechnology-based therapeutic approaches for effective anti-tuberculosis drug delivery and promising recent developments for diagnostic purposes. [ALTMETRIC and CITATIONS](https://precisionnanomedicine.net/prnano-1072023) Kaushik A, Singh RK, Tyagi PK, Green Synthesized Nanoparticle-Based Drug Delivery: Recent Trends and Future Prospects, [Precis. Nanomed. 2023, 6(3):1109-1132](https://doi.org/10.33218/001c.89165) POTENTIAL CLINICAL SIGNIFICANCE _From the Clinical Editor:_ The authors adopted a novel and intriguing approach in this review by describing the possible integration between nanomedicine and Ayurveda, the Indian traditional medicine using natural remedies. This combination can utilize the power of precision of nanotechnology to optimize Ayurveda’s holistic approach and further enhance the concept of personalized medicine. [ALTMETRIC and CITATIONS](https://precisionnanomedicine.net/prnano-1082023)